PT-141 (Bremelanotide)
Vyleesi — approved specifically for low sexual desire in premenopausal women.
Last Verified: August 14, 2026
Tier 1 — FDA-Approved Prescription Medication
Bremelanotide is a real, regulated drug with clinical trial data behind its one approved use, available only by prescription. This page describes that approved use and standard prescribing information — that's public medical information about a regulated drug, not personalized medical advice. Talk to your doctor about whether it's appropriate for you.
How It Works
"PT-141" is the research code name for bremelanotide, a synthetic peptide that activates melanocortin receptors (mainly MC4R) in the brain rather than acting on sex hormones or blood flow directly — a different mechanism from erectile-dysfunction drugs like sildenafil, which work on blood vessels. Activating this brain pathway is the proposed basis for its effect on sexual desire.
FDA-Approved Use
Approved in 2019 as Vyleesi, specifically for acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women — low sexual desire that causes marked distress and isn't better explained by another medical, relationship, or psychiatric issue, or by medication side effects. It is not approved for men, for postmenopausal women, or for any use outside this specific diagnosis.
FDA — Vyleesi Prescribing Information →
Standard Prescribing Information
Vyleesi is self-administered via a prefilled autoinjector into the abdomen or thigh, at least 45 minutes before anticipated sexual activity, as needed rather than on a daily schedule. Labeling advises no more than one dose within 24 hours and no more than 8 doses per month. This is general public prescribing information, not a personalized recommendation — your prescriber determines whether and how to use it in your case.
Side Effects & Who Should Be Cautious
Each dose can cause a temporary rise in blood pressure and drop in heart rate, typically resolving within about 12 hours — a reason it's used cautiously, and generally avoided, in people with uncontrolled high blood pressure or known cardiovascular disease. Nausea is common, especially with the first doses, along with flushing and headache. It can also temporarily darken skin and gums with frequent, long-term use.