Anti-Inflammatory Diet

A loosely defined, Mediterranean-style pattern. Plenty of research links it to lower inflammation, but most of it is observational.

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What Is the Anti-Inflammatory Diet?

The "anti-inflammatory diet" isn't one official plan. It's a general name for eating patterns built around foods that research has linked to lower markers of chronic, low-grade inflammation in the body. That means vegetables, fruit, whole grains, legumes, nuts, olive oil, and fatty fish, with fewer refined carbohydrates, fried foods, sugary drinks, and red and processed meats. Different sources publish somewhat different food lists, and there's no governing body, fixed rulebook, or calorie target.

In practice it overlaps heavily with the Mediterranean diet, and Harvard Health points to the Mediterranean diet as an example of an eating plan that follows anti-inflammatory principles.

How It Works

The idea is that some foods and nutrients nudge inflammation markers up and others nudge them down. The markers include C-reactive protein (CRP) and signaling molecules like interleukin-6 (IL-6) and TNF-α. Eating more of the second group and less of the first is meant to shift the overall balance.

Much of the research uses the Dietary Inflammatory Index (DII), a scoring tool researchers at the University of South Carolina built from roughly 1,900 published studies. It scores 45 foods and nutrients on whether they raised, lowered, or had no effect on six inflammation markers, then rates a whole diet from more pro-inflammatory (higher score) to more anti-inflammatory (lower score). The DII is a research tool, not a meal plan. Following the diet day to day just means leaning toward the lower-scoring foods.

Like the Mediterranean diet, it has no built-in calorie or macro structure. Total calories still determine weight change.

The Research

The honest summary: there's a large body of research linking more pro-inflammatory diets to worse health outcomes, but nearly all of it is observational. That shows association, not cause and effect. The strongest trial evidence comes from Mediterranean-diet studies that measured inflammation markers, not from trials of an "anti-inflammatory diet" as its own named plan.

Scoring tool: Shivappa N, Steck SE, Hurley TG, Hussey JR, Hébert JR. "Designing and developing a literature-derived, population-based dietary inflammatory index," Public Health Nutrition, 2014. Screened about 6,500 articles and scored 1,943 of them to rate 45 food parameters against six inflammation markers (IL-1β, IL-4, IL-6, IL-10, TNF-α, and CRP).

Read the paper →

Umbrella review (observational): Marx W, Veronese N, Kelly JT, et al. "The Dietary Inflammatory Index and Human Health: An Umbrella Review of Meta-Analyses of Observational Studies," Advances in Nutrition, 2021. Across 15 meta-analyses covering 38 health outcomes and over 4.3 million people, more pro-inflammatory diets were significantly associated with 27 of the 38 outcomes. When the authors graded how credible that evidence was, only one outcome (heart attack) reached "convincing." Several (all-cause mortality, overall cancer, and some site-specific cancers) were "highly suggestive," and most of the rest were suggestive, weak, or showed no association. The authors concluded that "the strength of evidence for most outcomes was limited."

Read the umbrella review →

Randomized trials (Mediterranean diet): Schwingshackl L, Hoffmann G. "Mediterranean dietary pattern, inflammation and endothelial function: a systematic review and meta-analysis of intervention trials," Nutrition, Metabolism & Cardiovascular Diseases, 2014. Across 17 randomized trials (2,300 adults, at least 12 weeks each), Mediterranean-style diets lowered high-sensitivity CRP (by about 1 mg/L) and IL-6 more than comparison diets, and improved a measure of blood-vessel function. The results varied a lot between trials, especially for CRP.

Read the meta-analysis →

Food Examples

Emphasized: tomatoes, olive oil, leafy greens (spinach, kale, collards), nuts (almonds, walnuts), fatty fish (salmon, mackerel, tuna, sardines), and fruit (strawberries, blueberries, cherries, oranges), per Harvard Health's list, plus the whole grains, legumes, herbs, and spices common to Mediterranean-style eating.

Limited: refined carbohydrates (white bread, pastries), fried foods, soda and other sugar-sweetened drinks, red meat and processed meat, and margarine, shortening, and lard. These are limited rather than banned.

A Sample Day

Breakfast: oatmeal with blueberries, walnuts, and a sprinkle of cinnamon.

Lunch: spinach salad with chickpeas, tomatoes, olive oil, and a whole-grain roll.

Snack: an orange and a handful of almonds.

Dinner: baked salmon, roasted vegetables, and quinoa.

Who It Might Suit

Tends to suit people who want a flexible, food-quality pattern without calorie counting or strict rules, and who like the general shape of Mediterranean-style eating. It's worth being realistic about what it can do. The research mostly shows associations and modest changes in blood markers, not proof that the diet treats any specific inflammatory condition. Anyone with a diagnosed inflammatory or autoimmune condition should treat it as a complement to medical care, not a replacement. Like the Mediterranean diet, it may be less practical on a tight food budget, and fish or tree-nut allergies require substitution. It has no weight-loss mechanism of its own, so pair it with a calorie or macro target if you have a weight goal.